The 4th International Symposium on Isotopomers (ISI2008)

Odaiba, Tokyo, Japan, 4-8 October 2008

2nd Circular and Call for Papers (released on 23 May, Last updated on 17 September 2008)

Dear Colleague,

Excuse me for the delay in sending you the 2nd circular of ISI. Now, the science and organizing committees of ISI 2008 are inviting you to participate in the Forth International Symposium on Isotopomers. The symposium will be held at National Museum of Emerging Science and Innovation (Kagaku Miraikan in Japanese) ( on 4-8 Oct., 2008 in Odaiba area, the Tokyo water front. The registration and an icebreaker party are scheduled on 4th Oct. The sessions are in the daytime from 5th to 8th Oct. covering isotope studies of important molecules, and the symposium banquet is scheduled in the evening of 6 Oct. The updated information is available at the URL:

Background and objectives

Isotopes have been used to trace material cycles in the solar system, planets, atmosphere, oceans, terrestrial environment, the biosphere, and also inside of the living organisms. Research is now developing from the determination of the bulk content of a single isotope to multi-isotope, mass independent fractionation (MIF) of oxygen and sulfur isotopes, doubly substituted isotopomers, and site specific tracer analysis at the molecular level: these new approaches constitute the study of isotopomers. The progress of several analytical techniques, such as Laser Ablation, Nuclear Magnetic Resonance (NMR), Continuous Flow-Isotope Ratio Mass Spectrometer (CF-IRMS), Tunable Diode Laser Absorption Spectroscopy (TDLAS) and others, permits these analysis; MIF, clumped isotopes, site-specific analysis of isotopes at natural abundance level, thus providing invaluable information for a better understanding of biogeochemical processes occurring in nature. Site specific labeled isotopomers allow the study of biochemical mechanisms and pathways, the response of organisms to agents of chemical change and of metabolic networks. The study of isotopomers has an increasing number of applications in numerous scientific fields ranging from earth and planetary sciences, environmental studies (including global warming) to life sciences relevant to many areas of interests for human activities (agriculture, food authentication, pharmacology, health care etc.). Mass independent isotope fractionation and clumped isotope measurements have developed into a new field of applications, ranging from solar system evolution to paleo and present atmospheric chemistry.

Scope and topics

The purpose of the Symposium is to look into the latest scientific achievements in the measurement and analysis of isotopomers, from the studies of planetary sciences to extended applications in environmental and life sciences including food authenticity and biomedical research. Mass independent chemical measurements and theory are also included. The Symposium will call for papers from a wide range of research on isotope-containing molecules with site-specific information and/or multi-isotopic measurements, as follows:

a. Life and Atmospheric Evolution
b. Global Change and Material Cycles
c. Application of Food Analysis and Authentication
d. Biomedical and Metabolic Applications
e. Theory and Simulations of Fractionation
f. Advances in Measurements

The papers to be presented at the Symposium will comprise invited papers, accepted oral and poster papers. In addition to more experienced researchers, the participation by younger generations of the isotope and/or isotopomer community as well as newcomers to the community is especially encouraged.

There will be a joint symposium related to the COE-program on Habitable Planets (COEHP) before ISI. The details of the COE-program on Habitable Planets are on the web pages, where you may find out some related sessions to ISI. You may also attend this symposium without extra charge except for the banquets. The following activities are scheduled from 27 Sept. to 8 Oct. 2008.

27 Sept. Outreach program (1)
28 Sept. Symposium: Research Perspective of COE21 "How to Build Habitable Planets?" (Multidisciplinary Researches on Habitable Planet), Registration and Icebreaker
29 Sept. - 3 Oct. International Symposium of "From Genome to Snowball Earth"

29 Sept. Phylogenic Evolution; Genome vs Paleontology
30 Sept. Surface Environmental Change
1 Oct. Role of Solid Earth and Modeling
2 Oct. Modeling of Snowball Earth, banquet
3 Oct. Habitable Planets in the Universe

4 Oct. Outreach program (2), Registration and Icebreaker for ISI2008
5 Oct. ISI
6 Oct. ISI, banquet
7 Oct. ISI
8 Oct. ISI

Conference Language


Conference Proceedings

Will be published

Short history and forthcoming symposia

The 1st ISI was held in 2001 in Yokohama, Japan, the 2nd ISI in 2003 in Stresa, Italy, and the 3rd ISI in 2006 in La Jolla, USA. Thanks to the great effort and enthusiasm of the hosts, science and organizing committee members, and the attendants, the last 3 symposia were really successful. Now, we would like to announce that the 4th ISI will be held in Tokyo, Japan from 4th to 8th, Oct., 2008. You may find the archives of the URLs of those symposia at the following URL; The next 5th ISI will be held in Amsterdam, The Netherlands, in late June, 2010.

Science committee

Dr. Naohiro Yoshida, Chair, Tokyo Institute of Technology, Japan
Dr. Pradeep Aggarwal, International Atomic Energy Agency, Austria
Dr. Thomas Brenna, Cornell University, USA
Dr. Matthew Johnson, University of Copenhagen, Denmark
Dr. Claude Guillou, European Commission, Italy
Dr. Roberto Gonfiantini, Institute of Geosciences and Georesources, Italy
Dr. Masahiro Kajiwara, Meiji Pharmaceutical Univ., Japan
Dr. Yasuko Kasai, National Institute of Information and Communications Technology, Japan
Dr. Naohiko Ohkouchi, Japan Agency for Marine-Earth Science and Technology,Japan
Dr. Gerald Remaud, University of Nantes, France
Dr. Andreas Rossmann, Technical Univ. Munich, Germany
Dr. Hiroyuki Sasada, Keio Univ., Japan
Dr. Mark Thiemens, Univ. California San Diego, USA
Dr. Frank Tittel, Rice University, USA
Dr. Eitaro Wada, Japan Agency for Marine-Earth Science and Technology, Japan

Organizing committee

Dr. Naohiro Yoshida, Tokyo Institute of Technology, Japan
Dr. Claude Guillou, European Commission, Italy
Dr. Keisuke Koba, Tokyo Univ. Of Agriculture and Technology, Japan
Dr. Toshi Nagata, Univ. of Tokyo, Japan
Ms. Mitsuko Nishijima, Tokyo Institute of Technology, Japan
Dr. Antra Pandey, Tokyo Institute of Technology, Japan
Dr. Thomas Roeckmann, Utrecht University, The Netherlands
Dr. Sebastian Danielache, Tokyo Institute of Technology, Japan
Dr. Eiichi Takahashi, Tokyo Institute of Technology, Japan
Dr. Mark Thiemens, Univ. California San Diego, USA
Dr. Sakae Toyoda, Tokyo Institute of Technology, Japan
Dr. Kiyoshi Tsuji, Tokyo Institute of Technology, Japan
Dr. Yuichiro Ueno, Tokyo Institute of Technology, Japan
Dr. Keita Yamada, Tokyo Institute of Technology, Japan
Dr. Chisato Yoshikawa, Tokyo Institute of Technology, Japan

Date and Venue of the Symposium

The Symposium will be held for 5 days from 4th to 8th Oct. (Saturday to Wednesday) in 2008. Registration and icebreaker party is scheduled in the evening of 4th Oct. The sessions are in the daytime from 5th to 8th Oct. and the symposium banquet is scheduled in the evening of 6 Oct. at the Hotel Nikko Tokyo. The venue for the Symposium is National Museum of Emerging Science and Innovation (Kagaku Miraikan in Japanese) (URL: ) 100m to the Tokyo Bay.

Important dates of the Symposium

The schedule of the Symposium is as follows:

15 Aug. 2008: Deadline for submission of short abstract of less than 100 words for the review for the program.
22 Aug. 2008: Deadline for early online registration.
31 Aug. 2008: Deadline for online hotel reservation.
14 Sept. 2008: Deadline for submission of extended abstracts. Deadline for online registration. Final announcement.
4-8 Oct. 2008: International Symposium on Isotopomers, submission of manuscripts for the proceedings.

The web site ( is being updated.


All participants should complete the Symposium Registration Form which is available at (English) (Japanese)
together with the payments for registration (including icebreaker, lunch, extended abstract and proceedings), banquet, and hotel accommodation separately.

Registration Fee regular person student, accompanying person
registration by 22 Aug. 2008 \35,000 \25,000
registration after 22 Aug. 2008 \45,000 \30,000
one day registration \15,000 \10,000
one banquet \10,000 \10,000

*Registration as a student is only possible with a certificate from your university/institute attached to the registration form. If the registration form is not accompanied by proof of student status, the normal fee will be applied.

Cancellation Policy

For registration and banquet cancellation, a written request should be sent by e-mail or fax to JTB Office:

By 19 Sept. 2008: 80% of the remitted amount will be refunded after the symposium.
By 25 Sept. 2008: 50% of the remitted amount will be refunded after the symposium.
After 25 Sept. 2008: There will be no refund. However, a copy of the Symposium Abstracts will be sent to the applicant after the symposium.

Abstract and Proceedings

Extended abstracts are distributed at the registration desk. The proceedings of the symposium will be published in camera-ready form as a CD ROM by the LOC soon after the symposium.

Instruction for authors

Details of the format of the extended abstracts and proceedings are here.

Letter of Invitation

If requested by a participant, the Organizing Committee will send a letter of invitation. This invitation letter is intended specifically to assist the participant in obtaining travel funds or appropriate visas and does not imply any financial support. Written requests in any form should be sent to Symposium Secretariat (

Travel Support

Limited travel support is available for the scientists who may have difficulties in obtaining travel fund to attend the Symposium. Because of the limited amount of funding available for this purpose, the Organizing Committee reserves the right to decide who will receive travel support. To request travel support either fully or partly, please contact the Symposium Secretariat (


The Local Organizing Committee of the Symposium has reserved sufficient rooms at discount convention rates to accommodate all participants and accompanying persons. The Hotel Reservation is available at the web site (web site prepared by JTB which will be shown in

Travel Related Information

Passports and Visas

All foreign visitors entering Japan must have a valid passport. Participants should obtain a visa, if required, from a Japanese Consulate or diplomatic mission in their home country prior to their departure. It is the responsibility of participants to obtain all documents necessary for entry into Japan. For details, you are advised to contact their local travel agent or air carrier.


We recommend Japan National Tourist Organization (JNTO) as a source of information on Japan in general, concerning travel geography, language, communication, and other matters. JNTO is an arm of the Ministry of Foreign Affairs, and has offices in major cities throughout the world. Contact the office nearest to you to ask any questions or to obtain maps, brochures, and other documents, all free of charge. Information on JNTO, including a list of its overseas offices, is found on the homepage at Optional tours will be available in the URL, and please contact it individually:

Odaiba Area

Odaiba is a large artificial island in Tokyo Bay, Japan, across the Rainbow Bridge from central Tokyo. It was initially built for defensive purposes in the 1800s, dramatically expanded during the late 20th century as a seaport district, and has developed since the 1990s as a major commercial, residential and leisure area. (URL:

Climate and Clothing

The climate in Tokyo during the period of the conference will be moderate between 15 and 25 degree C. All the Symposium rooms are air-conditioned. Attendants are advised to bring some light clothing.

Currency Exchange

Only Japanese yen (\) is acceptable at regular stores and restaurants. Credit cards may be used at hotels, restaurants and souvenir shops. Yen can be purchased at foreign exchange banks and authorized money changers on presentation of your passport. The exchange rate fluctuates daily, but the U.S. Dollar and Euro is equivalent to 105 and 160 Yen, respectively in May, 2008.

Traveler’s Checks and Credit Cards

Using traveler’s checks is not so popular in Japan. Traveler’s checks are accepted only by leading banks and major hotels in major cities. American Express, Diners Club, MasterCard and VISA are widely accepted at hotels, department stores, restaurants, and nightclubs.

Tipping and Service Charge

You will be free from tipping worries since it is not common practice in Japan. However, some restaurants add a 10-20% service charge as well as a 5% consumption tax to each bill.

Access to National Museum of Emerging Science and Innovation (Kagaku Miraikan in Japanese)

Most international flights arrive at New Tokyo International Airport (Narita).

a) Airport limousine bus to the hotels listed on the registration web page

Airport limousine bus is available from Narita Airport to the hotels listed on the registration web page (URL:

1) To the hotels in Odaiba area : 65 min.-75 min. \2700

Free shuttle bus is available every 15-25 minutes, from11:00am to 8:00pm from the hotels to Kagaku Miraikan (URL:

2) To Mitsui Garden Hotel Ginza Premier: 89-90min. \3000
Time table of airport limousine busses at 2nd terminal (departure time at 1st terminal is 5-10 min later)
To hotels 1) To hotels 2)
8:45 7:45
10:50 10:40
13:50 12:15
15:50 13:45
16:50 14:45
17:50 15:45
18:50 16:45

b) Airport limousine bus to TCAT

Airport limousine buses are available from Narita Airport to Tokyo City Air Terminal (TCAT). They depart from the airport arrival lobbies and are operated between 6:55A.M. and 11:00P.M. at 10-30 minutes intervals. It takes about 60 minutes from the airport to TCAT(one way fare:\2,900).
TCAT(Suitengu-mae Station)−Mitsukoshi-mae: Tokyo Metro Hanzomon Line, 2 min. 
Mitsukoshi-mae−Shinbashi: Tokyo Metro Ginza Line, 7 min.
Shinbashi−Funeno-kagakukan: Yurikamome Line, 15 min.
Funeno-kagakukan−Kagaku Miraiknan: 5 min. walk

c) JR Narita Express Train to Tokyo

The JR Narita Express provides a direct connection from Narita to Tokyo station. The Narita Express leaves Narita Airport at hourly intervals between 7:43AM and 9:43 PM. Running time is about 60 minutes, \2940).
Tokyo−Shinbashi: JR Yamanote Line or Keihin-tohoku Line, 3 min.
Shinbashi−Funeno-kagakukan: Yurikamome Line, 6 min.
Funeno-kagakukan−Kagaku Miraiknan: 5 min. walk

d) JR Narita Express Train to Shinagawa

Some Narita Express trains stop at Shinagawa Station (90 minutes, \3110).
Shinagawa−Oimachi: JR Keihin-tohoku Line, 4 min.
Oimachi−Tokyo Teleport: Rinkai Line, 7 min.
Tokyo Teleport−Kagaku Miraikan: free shuttle bus

e) Taxi Information

We do not recommend you to take a taxi from Narita airport to Tokyo. It will cost more than \30,000.
From Shinbashi Station to Odaiba area: approximately 30 minutes, about \3000
from Tokyo Station to Odaiba area: approximately 35 minutes, about \4000

* We would appreciate it if you could send a copy of the announcement to the scientists who might be interested in the Symposium but have not received this announcement. Please let us know if you can nominate potential contributors to the Symposium.


Scientific Contents of the Symposium

Naohiro Yoshida

Ph.D. Prof., Department of Environmental Science and Technology,Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology G1-25, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, JAPAN
Phone +81-45-924-5506 (office), Fax +81-45-924-5143

Secretariat of the Symposium

Ms. Mitsuko Nishijima

A secretary to 21 COE and Dr. N. Yoshida Department of Environmental Science and Technology Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology G1-25, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, JAPAN
Phone +81-45-924-5506 (office), Fax +81-45-924-5143

Registration and Accommodation

Mr. Mitsuhiro Kurosu / Ms. Tomomi Tsukayama / Mr. Yosuke Tanaka

JTB Tokyo Metropolitan Corp. Corporate Sales Office, Yokohama 6F, Yasuda 6th Bldg., 3-29-1, Tsuruya-cho, Kanagawa-ku, Yokohama 221-0835, JAPAN
Tel.+81-45-316-4602 Fax.+81-45-316-5701

When you have any inquiries, please do not hesitate to contact either Dr. Naohiro Yoshida, Ms. Mitsuko Nishijima, Mr. Mitsuhiro Kurosu, Ms. Tomomi Tsukayama, or Mr. Yosuke Tanaka.

To the Home page of Naohiro Yoshida's Laboratory @Tokyo Tech